HOMA-IR
Medical context
Estimate insulin resistance from fasting glucose and insulin (HOMA-IR).
Primary and hospital medicine teams use this for everyday internal medicine workflows.
This page explains the HOMA-IR formula, how to interpret the output, known limitations, and peer-reviewed references so you can verify results against primary sources and local protocols.
It is grouped under General Medicine because everyday internal medicine calculators.
How to use this calculator
- Enter the values requested by the HOMA-IR calculator using the units shown beside each field.
- Review the calculated result and read the interpretation section before acting on the output.
- Check limitations and references if the result will change management, dosing, or disposition.
- Use the related calculators section when you need supporting values (for example electrolytes, weight, or complementary risk scores).
Calculator
Result
2.22
HOMA-IR (fasting glucose × insulin / 405)
Educational use only. Confirm results with clinical judgment, primary sources, and local protocols. Not a substitute for professional medical advice. Full disclaimer.
Formula
HOMA-IR = (glucose mg/dL × insulin µU/mL) / 405.
Interpretation
Higher values suggest greater insulin resistance; cutoffs are assay- and population-specific.
Limitations
Not a diagnostic criterion for diabetes; fasting samples required.
Frequently asked questions
- What is a normal HOMA-IR?
- Often <1.9–2.0 is considered more insulin-sensitive, but local reference ranges vary.
- Is the HOMA-IR result enough to make a treatment decision?
- No. Calculators support medical decision-making but do not replace examination, shared decision-making, institutional protocols, or consultant input when stakes are high.
- Does Calcmedical store the values I type in?
- Inputs are processed in your browser for this session. We do not ask for patient names or medical record numbers. See our privacy policy for hosting and analytics details.
References
- Matthews DR et al. HOMA model